S-Adenosylmethionine (SAMe) is the active methyl form of the amino acid methionine. SAMe is necessary for an array of biochemical pathways, including neurotransmitter synthesis, metabolism of homocysteine, and detoxification. As a donator of methyl groups, SAMe supports glutathione production, liver health, musculoskeletal and joint comfort, and a positive mood. This formulation of SAMe includes 5-methyltetrahydrofolic acid (5-MTHF), as pathways using SAMe are dependent on this methylated cofactor.